A novel probe for imaging amyloid-β: Synthesis of F-18 labelled BF-108, an acridine orange analog

Hiroshi Shimadzu, Takahiro Suemoto, Masako Suzuki, Tsuyoshi Shiomitsu, Nobuyuki Okamura, Yukitsuka Kudo, Tohru Sawada

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The synthesis of 3-(2-[18F]fluoroethyl)ethylamino-6-diethylaminoacridine ([18F]BF-108), a potential positron-labelled probe for imaging amyloid-β is described. The precursor tosylate derivative was fluorinated with [18F]KF/Kryptofix 222 in acetonitrile, and the crude product was purified by semipreparative HPLC to give the radiolabelled BF-108. The radiochemical purity was >95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB).

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number8
DOIs
Publication statusPublished - 2003 Jul 1

Keywords

  • 3-(2-fluoroethyl)ethylamino-6-diethylaminoacridine
  • Amyloid-β
  • BF- 108
  • F
  • PET

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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