A novel PHBV/HA microsphere releasing system loaded with alendronate

Wei Huang, Yingjun Wang, Li Ren, Chang Du, Xuetao Shi

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)

    Abstract

    Microspheres of poly(β-hydroxybutyrate-co-β-hydroxyvalerate) (PHBV) incorporated with hydroxyapatite (HA) and loaded with alendronate (AL), an osteoporosis preventing drugs, were prepared by single emulsion technique. Several methods were used to evaluate this novel drug carrier microsphere system (referred as PHBV/HA-AL). Fourier transform infrared (FTIR) was used to evaluate the enwrapping of HA and the X-ray diffraction (XRD) analysis further confirmed the success. The morphology of PHBV/HA-AL microspheres was observed by scanning electron microscope (SEM), showing rough surface with HA particles enwrapped in the PHBV matrix. The in vitro drug releasing profile of PHBV/HA-AL system was investigated in a 26-day period. There is a sustained releasing pattern after a slight burst release during the first few days. Additionally, rabbit mesenchymal stem cells (MSCs) were used to evaluate the cytotoxicity of the PHBV/HA-AL composites. This controlled release system can well support the proliferation of MSCs. The novel PHBV/HA-AL controlled release system is promising for bone repair therapy.

    Original languageEnglish
    Pages (from-to)2221-2225
    Number of pages5
    JournalMaterials Science and Engineering C
    Volume29
    Issue number7
    DOIs
    Publication statusPublished - 2009 Aug 31

    Keywords

    • Alendronate
    • Bone repair
    • Controlled release
    • Microsphere
    • PHBV

    ASJC Scopus subject areas

    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering

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