A novel palladium-catalyzed coupling of thiol esters with 1-alkynes

Hidetoshi Tokuyama, Tohru Miyazaki, Satoshi Yokoshima, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

A new method for synthesizing α,β-acetylenic ketones by palladium-mediated coupling of thiol esters with 1-alkynes is described. The reaction could be applied to coupling of thiol esters bearing various functional groups, such as aromatic bromides, and ketones, with functionalized terminal acetylenes.

Original languageEnglish
Pages (from-to)1512-1514
Number of pages3
JournalSynlett
Issue number10
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • 1-alkynyl ketones
  • Copper
  • Palladium
  • Sonogashira-type coupling reaction
  • Thiol esters

ASJC Scopus subject areas

  • Organic Chemistry

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