A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes

Hisashi Okimoto, Yasushi Ishigaki, Yoshihiro Koiwa, Yoshinori Hinokio, Takehide Ogihara, Susumu Suzuki, Hideki Katagiri, Takayoshi Ohkubo, Hideyuki Hasegawa, Hiroshi Kanai, Yoshitomo Oka

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We recently developed a novel method for evaluating the elasticity of arterial walls, the phased tracking method. Herein, we evaluated atherosclerosis of the carotid artery with this method in 242 individuals with type 2 diabetes. In multiple regression analysis of subject status, age, systolic blood pressure and hyperlipidemia were found to be independently associated with carotid artery elasticity values. We also measured currently established values for atherosclerosis, carotid artery IMT and baPWV, in these subjects. Carotid artery elasticity correlated with max IMT (r = 0.291, p < 0.01), plaque score (PS) (r = 0.220, p < 0.01) and baPWV (r = 0.345, p < 0.01). Elasticity, max IMT and plaque score, all correlated with the number of risk factors for atherosclerosis, i.e. hypertension, hyperlipidemia and smoking, in addition to diabetes, consistent with the view that these values reflect atherosclerosis. Importantly, however, in subjects with IMT <1.1 mm, who are classified as not having atherosclerosis as defined by IMT criteria, only carotid artery elasticity correlated with the number of risk factors (p < 0.05). These results suggest that (1) the measured carotid artery elasticity values reflect atherosclerosis and (2) our novel method has potential for detecting atherosclerosis in its early stage.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalAtherosclerosis
Volume196
Issue number1
DOIs
Publication statusPublished - 2008 Jan

Keywords

  • Atherosclerosis
  • Diabetes
  • Human carotid artery elasticity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes'. Together they form a unique fingerprint.

  • Cite this