A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart

Yasuhiro Tomita, Dong Ho Kim, Kenta Magoori, Takahiro Fujino, Tokuo T. Yamamoto

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

We report herein the identification of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 4 (LRP4). Murine LRP4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters. Southern blot analysis of genomic DNA from several different organisms suggests the presence of LRP4 homologues in chicken lacking the gene encoding apolipoprotein E, which is recognized by the ligand-binding repeats of LDLR. LRP4 transcripts were detected almost exclusively in heart in mouse and humans. Despite the presence of the ligand-binding repeats, COS cells transfected with LRP4 did not show surface-binding of β-migrating very-low-density lipoprotein, suggesting that LRP4 plays a role in a pathway other than lipoprotein metabolism.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalJournal of biochemistry
Volume124
Issue number4
DOIs
Publication statusPublished - 1998 Oct

Keywords

  • LDL receptor family
  • LDL receptor related protein
  • Membrane protein
  • Receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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