A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

Hidetoshi Tokuyama, Satoshi Yokoshima, Tohru Yamashita, Tohru Fukuyama

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

A variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydes, tolerate the reaction conditions. The reaction can also be applied to the synthesis of α-amino ketones using the corresponding L-α-amino thiol esters without racemization.

Original languageEnglish
Pages (from-to)3189-3192
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number20
DOIs
Publication statusPublished - 1998 May 14
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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