A novel gene ″Niban″ upregulated in renal carcinogenesis: Cloning by the cDNA-amplified fragment length polymorphism approach

Shuichi Majima, Kazunori Kajino, Tomokazu Fukuda, Fujio Otsuka, Okio Hino

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A modified AFLP (amplified fragment length polymorphism) method was employed to isolate genes differentially expressed in renal carcinogenesis of Tsc2 gene mutant (Eker) rats. One gene, selected for further investigation, was named ″Niban″ (″second″ in Japanese), because it is the second new gene to be found after Erc (expressed in renal carcinoma) in our laboratory. Importantly, ″Niban″ is well expressed even in small primary rat Eker renal tumors, more than in progressed cell lines, and is also expressed in human renal carcinoma cells, but not in normal human or rat kidneys. Chromosome assignment was to RNO 13 in the rat, and HSA 1. This ″Niban″ gene is a candidate as a marker for renal tumor, especially early-stage renal carcinogenesis.

Original languageEnglish
Pages (from-to)869-874
Number of pages6
JournalJapanese Journal of Cancer Research
Volume91
Issue number9
DOIs
Publication statusPublished - 2000

Keywords

  • CDNA-AFLP
  • Multistep renal carcinogenesis
  • Tsc2 gene mutant (Eker) rats
  • Tumor marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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