A novel function of geranylgeraniol in regulating testosterone production

Hsin Jung Ho, Hitoshi Shirakawa, Puspo E. Giriwono, Asagi Ito, Michio Komai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH’s ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities. It is noteworthy that GGOH regulates the steroidogenesis pathway in testis-derived I-10 tumor cells. Testosterone is a hormone produced via steroidogenesis in testicles and plays a role in fetal development and the male reproductive system. GGOH enhanced testosterone and progesterone (its precursor) levels in I-10 cells by activating adenylate cyclase via cAMP/PKA signaling, without altering phosphodiesterase activity. These findings highlight the potential benefits of GGOH as a therapeutic agent for low testosterone levels, such as late-onset hypogonadism in men.

Original languageEnglish
Pages (from-to)956-962
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume82
Issue number6
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • CamP/ PKa
  • Geranylgeraniol
  • Progesterone
  • Steroidogenesis
  • Testosterone

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A novel function of geranylgeraniol in regulating testosterone production'. Together they form a unique fingerprint.

  • Cite this