A novel function of geranylgeraniol in regulating testosterone production

Hsin Jung Ho, Hitoshi Shirakawa, Puspo E. Giriwono, Asagi Ito, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    Isoprenoids play widely differing roles in various physiological processes in animals and plants. Geranylgeraniol (GGOH) is an isoprenoid found in plants, and is an important metabolic derivative in the isoprenoid/cholesterol synthesis pathway. Earlier studies focused on GGOH’s ability to improve the side effects of bisphosphonate therapy by regulating the mevalonate pathway. More recently, the mevalonate pathway-independent effects of GGOH have been described, including anti-inflammatory, anti-tumorigenic, and neuroprotective activities. It is noteworthy that GGOH regulates the steroidogenesis pathway in testis-derived I-10 tumor cells. Testosterone is a hormone produced via steroidogenesis in testicles and plays a role in fetal development and the male reproductive system. GGOH enhanced testosterone and progesterone (its precursor) levels in I-10 cells by activating adenylate cyclase via cAMP/PKA signaling, without altering phosphodiesterase activity. These findings highlight the potential benefits of GGOH as a therapeutic agent for low testosterone levels, such as late-onset hypogonadism in men.

    Original languageEnglish
    Pages (from-to)956-962
    Number of pages7
    JournalBioscience, Biotechnology and Biochemistry
    Issue number6
    Publication statusPublished - 2018


    • CamP/ PKa
    • Geranylgeraniol
    • Progesterone
    • Steroidogenesis
    • Testosterone

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry


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