TY - JOUR
T1 - A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading
AU - Mori, S.
AU - Nose, Masato
AU - Morikawa, H.
AU - Sato, A.
AU - Saito, T.
AU - Song, S. T.
AU - Tanda, N.
AU - Teshima, T.
PY - 1998/11/1
Y1 - 1998/11/1
N2 - We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (+ +), weakly positive (+), and negative (-). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0-2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++ E-cad-, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44-, E-cad++, HS-GAG- , or L-PHA-. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC.
AB - We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (+ +), weakly positive (+), and negative (-). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0-2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++ E-cad-, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44-, E-cad++, HS-GAG- , or L-PHA-. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC.
KW - CD44
KW - E-cadherin
KW - Heparan sulfate glycosaminoglycan
KW - Metastasis
KW - Phaseolus vulgaris leukoagglutinin-binding oligosaccharides
KW - Squamous cell carcinoma
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U2 - 10.1016/S1368-8375(98)00048-7
DO - 10.1016/S1368-8375(98)00048-7
M3 - Article
C2 - 9930370
AN - SCOPUS:0031731486
VL - 34
SP - 549
EP - 557
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 6
ER -