TY - JOUR
T1 - A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading
AU - Mori, S.
AU - Nose, M.
AU - Morikawa, H.
AU - Sato, A.
AU - Saito, T.
AU - Song, S. T.
AU - Tanda, N.
AU - Teshima, T.
N1 - Funding Information:
We thank Professor Masahiko Mori (Asahi University, School of Dentistry, Gifu Prefecture, Japan) for critically reviewing the manuscript and encouragement. This work was supported by the Scientific Research Funds of the Ministry of Education, Science and Culture of Japan.
PY - 1998/11
Y1 - 1998/11
N2 - We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (+ +), weakly positive (+), and negative (-). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0-2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++ E-cad-, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44-, E-cad++, HS-GAG- , or L-PHA-. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC.
AB - We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (+ +), weakly positive (+), and negative (-). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0-2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++ E-cad-, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44-, E-cad++, HS-GAG- , or L-PHA-. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC.
KW - CD44
KW - E-cadherin
KW - Heparan sulfate glycosaminoglycan
KW - Metastasis
KW - Phaseolus vulgaris leukoagglutinin-binding oligosaccharides
KW - Squamous cell carcinoma
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U2 - 10.1016/S1368-8375(98)00048-7
DO - 10.1016/S1368-8375(98)00048-7
M3 - Article
C2 - 9930370
AN - SCOPUS:0031731486
VL - 34
SP - 549
EP - 557
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 6
ER -
