A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading

S. Mori, Masato Nose, H. Morikawa, A. Sato, T. Saito, S. T. Song, N. Tanda, T. Teshima

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Histochemical patterns of expression of these markers were classified into positive (+ +), weakly positive (+), and negative (-). The histopathological grades and the histochemical patterns of the SCC were estimated on a 0-2 point scale, i.e. point 2 for poorly differentiated, mode 4D, CD44++ E-cad-, HS-GAG++, or L-PHA++; point 1 for moderately differentiated, mode 4C, CD44+, E-cad+, HS-GAG+, or L-PHA+; and point 0 for well differentiated, mode 1, mode 2, mode 3, CD44-, E-cad++, HS-GAG- , or L-PHA-. As a result, incidence of metastasis in the cases with a total score of more than 6 (62.8%) was significantly higher than that with a total score of less than 5 (9.3%). This evaluation system will yield useful information concerning the prognosis of patients with oral SCC.

Original languageEnglish
Pages (from-to)549-557
Number of pages9
JournalOral Oncology
Volume34
Issue number6
DOIs
Publication statusPublished - 1998 Nov 1

Keywords

  • CD44
  • E-cadherin
  • Heparan sulfate glycosaminoglycan
  • Metastasis
  • Phaseolus vulgaris leukoagglutinin-binding oligosaccharides
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'A novel evaluation system of metastatic potential of oral squamous cell carcinoma according to the histopathological and histochemical grading'. Together they form a unique fingerprint.

Cite this