A novel desensitizer paste containing calcium phosphate: Randomized, placebo-controlled, double-blinded and 6 months trial

Prashant Moogi, Maratham C. Rupesh, Deepak Mehta, Werner J. Finger, Keiichi Sasaki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: This study aims to investigate the effect of a calcium phosphate-based desensitizer paste on reduction of dentin hypersensitivity (DH). Materials and methods: This crossover study was designed as randomized, double-blinded, and placebo-controlled trial. Teethmate AP paste (TAP), containing tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) dispersed in a glycerol/polyethylene glycol paste, was compared with placebo (PLA), a calcium phosphate-free analog paste. A total of 45 patients with one hypersensitive cervical lesion in each of two contralateral quadrants were allocated to the trial when baseline sensitivity (pretreatment sensitivity score, PRE) on air-blast (AB) stimulation and probe scratching (PS) measured on a visual analog scale (VAS; 0–10) was ≥6. Patients were recalled after 1 day, 1 week, and 1, 3, and 6 months. One-way analysis of variance (ANOVA), Tukey’s post hoc test, and pairwise comparisons between TAP and PLA were conducted at all time points (α<0.05). Results: Both treatments reduced DH significantly during the 6-month course. Immediately after treatment (posttreatment sensitivity score, POST), TAP sensitivity on AB was reduced to 63%, after 6 months to 39% of the PRE score, and PS to 60 and 54% respectively. Application of PLA reduced AB sensitivity at POST and 6 months to 79 and 60%, and on PS stimulation to 79 and 67% respectively. At all time points, TAP and PLA were significantly different (p < 0.05). Conclusion: Teethmate AP paste is a biocompatible and effective desensitizing agent when used for the treatment of moderately severe DH. Clinical significance: Calcium phosphate-based desensitiz-ers are one of the most effective desensitizing agents and are expected to play an important role in the treatment of DH.

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalWorld Journal of Dentistry
Issue number6
Publication statusPublished - 2017 Nov 1


  • Calcium phosphate
  • Clinical trial
  • Desensitization
  • Placebo
  • Teethmate desensitizer

ASJC Scopus subject areas

  • Dentistry(all)


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