A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: A clinical trial

Masaaki Nakayama, Hirofumi Nakano, Hiromi Hamada, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Background. Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H2) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H2 and examined the clinical effects.Methods. Dialysis solution with H2 (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H2 generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.Results. During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified.Conclusions. Adding H2 to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

Original languageEnglish
Pages (from-to)3026-3033
Number of pages8
JournalNephrology Dialysis Transplantation
Volume25
Issue number9
DOIs
Publication statusPublished - 2010 Sep

Keywords

  • electrolysed water
  • haemodialysis
  • hydrogen water
  • inflammation
  • oxidative stress

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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