A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model

Ming Cai Zhang, Shiro Mori, Fumiko Date, Hiroshi Furukawa, Masao Ono

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: The incidence and characteristics of spontaneous ankylosis in the ankle of specific F1 mice descended from two Fas-deficient strains were reported. Here the coincidence of synovial proliferation and ankylosis in the descendent F2 mice is reported. Aim: To clarify whether the two distinct manifestations are genetically different. Methods: An arthropathic group of mice (MCF2) were bred by intercrossing MRL/Mp.Faslpr-sap-/sap- and C3H/He.Fas lpr mice. All mice were killed by bleeding under anaesthesia when they were 6 months old. Pathological grades for synovial proliferation were determined by microscopical examination. To obtain a linkage locus, the whole genome of male MCF2 mice was scanned by using 73 microsatellite markers. Results: Synovial proliferation was equally observed in male and female MCF2 mice. No correlation was observed between the grades of synovial proliferation and the ankylosis occurring in the MCF2 mice. A suggestive susceptibility locus was shown in the middle of chromosome 11. This locus was an MRL allele with a recessive inheritance mode. Conclusion: The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different. The present locus is overlapped with some loci associated with rheumatoid arthritis and with others associated with experimental arthritides.

Original languageEnglish
Pages (from-to)242-245
Number of pages4
JournalAnnals of the rheumatic diseases
Volume66
Issue number2
DOIs
Publication statusPublished - 2007 Feb

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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