A nitric oxide donor NOC 7 suppresses renal responses induced by norepinephrine and angiotensin II in the NO-depleted denevated rabbit kidney

Naoto Ono, Yuichiro Adachi, Kazuyuki Hashimoto, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Intrarenal arterial infusion of norepinephrine (30 ng/kg per rain) or of angiotensin II (4 ng/kg per min) reduced the glomerular filtration rate and urinary Na+ excretion in denervated kidneys of anesthetized rabbits pretreated intrarenally with a nitric oxide (NO) synthase inhibitor N(ω)- nitro-L-arginine methyl ester (50 μg/kg per min). Angiotensin II but not norepinephrine reduced fractional Na+ excretion. Intrarenal administration of a spontaneous NO donor 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3- methyl-1-triazene (NOC 7, 30 ng/kg per min) in L-NAME pretreated kidneys did not affect basal values, but attenuated the reduction in urinary Na+ excretion induced by these agonists without affecting the angiotensin II- induced reduction in glomerular filtration rate. The results suggest that NOC 7 can suppress the norepinephrine-induced hypofiltration and the angiotensin II-evoked tubular reabsorption and thereby attenuates the agonist-induced antinatriuresis in the denervated and endogenous NO-depleted rabbit kidney.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalEuropean Journal of Pharmacology
Volume342
Issue number2-3
DOIs
Publication statusPublished - 1998 Jan 26

Keywords

  • (Rabbit)
  • Angiotensin II
  • Kidney
  • N(ω)-nitro-L-arginine methyl ester (L-NAME)
  • NOC 7 (1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3- methyl-1-triazene)
  • Nitric oxide (NO)
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology

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