Abstract
A new type of amino amide organocatalysts was designed and synthesized from commercially available amino acids in easy steps. Their catalytic activities were examined in enantioselective crossed aldol reaction of various acyclic and cyclic ketones with aromatic aldehydes to afford the corresponding chiral anti-aldol adducts with good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to syn:anti = 1:99, up to 97% ee).
Original language | English |
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Pages (from-to) | 4705-4711 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 74 |
Issue number | 36 |
DOIs | |
Publication status | Published - 2018 Sep 6 |
Keywords
- Aldehydes
- Amino amide
- Crossed aldol reaction
- Ketones
- Organocatalysis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry