A new taxane composed of two N-formyl rotamers from Taxus canadensis

Man Li Zhang, Mei Dong, Xiao Ning Li, Li Geng Li, Fançoise Sauriol, Chang Hong Huo, Qing Wen Shi, Yu Cheng Gu, Hiromasa Kiyota, Bin Cong

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)


    A taxane with an amino-side chain on C-5 was identified for the first time from rooted cuttings of the Canadian yew, Taxus canadensis. The structure was characterized as 7β,9α,10β,13α-tetraacetoxy-5α-[3′-(N-formyl-N-methylamino)-3′-phenylpropanoyl]oxytaxa-4(20),12-diene (1) on the basis of 1D-, 2D-NMR data, and HR-FABMS analyses. The spectra revealed that in CDCl3 solution 1 was composed of two rotamers (1a and 1b) in a ratio of approximately 2:1.

    Original languageEnglish
    Pages (from-to)3405-3408
    Number of pages4
    JournalTetrahedron Letters
    Issue number21
    Publication statusPublished - 2008 May 19

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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