A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD

Takahiko Sasaki, Katsutoshi Nakayama, Hiroyasu Yasuda, Mutsuo Yamaya

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro. Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect.

Original languageEnglish
Pages (from-to)91-103
Number of pages13
JournalTherapeutic Advances in Respiratory Disease
Volume5
Issue number2
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • chronic obstructive pulmonary disease (COPD)
  • common cold
  • exacerbations
  • proton pump inhibitors (PPIs)
  • rhinovirus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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