A new combination chemotherapy with Cis-diammine-glycolatoplatinum (Nedaplatin) and 5-fluorouracil for advanced esophageal cancers

Takashi Yoshioka, Makio Gamoh, Ryusaburo Shineha, Satoru Ishibashi, Hiroyuki Shibata, Takao Suzuki, Yasuko Murakawa, Syunsuke Kato, Hideki Shimodaira, Satoshi Kato, Chikashi Ishioka, Ryunosuke Kanamaru

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Objective: The efficacy of a new chemotherapeutic combination consisting of Cis-diammine-glycolatoplatinum (Nedaplatin), a derivative of cisplatin (CDDP), and 5-fluorouracil (5FU) was evaluated in patients with advanced esophageal carcinomas. Methods: Nedaplatin was administered at a dose of 80 or 100 mg/m2 with 500 ml of saline by slow drip infusion for 120 minutes on day 1.5FU at a dose of 350 or 500 mg/m2 was mixed with 1,000 ml of saline and administered by continuous infusion for 24 hours on days 1 to 5. Patients or Materials: This combination chemotherapy was tried in 17 patients with metastatic, recurrent, or bulky unresectable esophageal cancers. Of these, 15 evaluable patients received at least two courses of chemotherapy. Results: The response rates in assessable and all patients were 60% and 52.9%, respectively. Cases with lymph node and liver metastases, as well as primary lesions, showed excellent response to the therapy with positive response rates of 54.5% (6/11), 100% (5/5) and 58.4% (7/12), respectively. The median response duration was 7 (range 3 to 37+) months for patients who achieved a partial response. Adverse drug reactions were limited to three cases of grade 3 toxicity, including allergy, and decreased hemoglobin and platelets, which were well tolerated by the patients. Conclusion: The present study thus indicated the combination chemotherapy of Nedaplatin and 5FU to be safe and efficacious for advanced esophageal cancer. Further investigations are clearly warranted.

Original languageEnglish
Pages (from-to)844-848
Number of pages5
JournalInternal Medicine
Volume38
Issue number11
DOIs
Publication statusPublished - 1999 Nov

Keywords

  • Antineoplastic agents
  • Cisplatin derivative
  • Drug effects
  • Squamous cell
  • Undifferentiated carcinoma

ASJC Scopus subject areas

  • Internal Medicine

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