A new and informative [a,b,c,d] nomenclature for one-pot multistep transformations: A simple tool to measure synthetic efficiency

Satrajit Indu, Krishna P. Kaliappan

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Domino, cascade and tandem reactions constitute the most efficient and creative chemical transformations with a huge domain of synthetic utility and applications. A number of reactions may be achieved in a single pot, accompanied by the formation of new rings and new bonds, leading towards higher molecular complexity. A lack of one unified, yet informative descriptor often understates the synthetic ingenuity of certain highly creative transformations. In this review, we propose a new tetra-coordinated [a,b,c,d] nomenclature which takes into account and displays the basic parameters which generally indicate the level of efficiency of a chemical transformation. An almost exhaustive set of one-pot multistep reactions may be described by this system and this review is an attempt to display the one-pot multistep transformations reported from our group and to classify them based on our proposed descriptor.

Original languageEnglish
Pages (from-to)21292-21305
Number of pages14
JournalRSC Advances
Volume8
Issue number38
DOIs
Publication statusPublished - 2018
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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