TY - JOUR
T1 - A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients
AU - Ichinose, Masakazu
AU - Miura, Motohiko
AU - Yamauchi, Hideyuki
AU - Kageyama, Natsuko
AU - Tomaki, Masafumi
AU - Oyake, Tatsuya
AU - Ohuchi, Yuzuru
AU - Hida, Wataru
AU - Miki, Hiroshi
AU - Tamura, Gen
AU - Shirato, Kunio
PY - 1996
Y1 - 1996
N2 - Recent reports suggest the involvement of vascular phenomena in exercise- induced asthma. Sensory neuropeptides, such as substance P (SP), which causes airway vascular dilatation and plasma leakage, have been demonstrated to play a role in hyperpnea-induced airway narrowing in animal studies. The purpose of this study was to investigate the importance of tachykinins in exercise- induced airway narrowing in patients with asthma using a selective neurokinin 1-receptor (NK1-receptor) antagonist, FK-888. In a double-blind, placebo- controlled, crossover trial, nine subjects with stable asthma were given FK- 888 (2.5 mg) or placebo by inhalation 20 min before each exercise at a level previously demonstrated to cause a fail of at least 40% in specific airway conduction (SGaw). Inhalation of FK-888 had no significant effect on baseline SGaw. While the recovery from exercise-induced airway narrowing was significantly faster after treatment with FK-888, the area under the curve for SGaw during the 50 min after exercise was significantly reduced (p < 0.05) and the time taken for the SGaw to recover to within 65% of baseline after exercise was also significantly shorter with FK-888 than with placebo (p < 0.05). However, treatment with FK-888 did not significantly attenuate the maximal fall in SGaw. These results suggest that NK1-receptor-mediated mechanisms are involved in the recovery phase of exercise-induced airway narrowing. The possible mechanisms of these phenomena are discussed.
AB - Recent reports suggest the involvement of vascular phenomena in exercise- induced asthma. Sensory neuropeptides, such as substance P (SP), which causes airway vascular dilatation and plasma leakage, have been demonstrated to play a role in hyperpnea-induced airway narrowing in animal studies. The purpose of this study was to investigate the importance of tachykinins in exercise- induced airway narrowing in patients with asthma using a selective neurokinin 1-receptor (NK1-receptor) antagonist, FK-888. In a double-blind, placebo- controlled, crossover trial, nine subjects with stable asthma were given FK- 888 (2.5 mg) or placebo by inhalation 20 min before each exercise at a level previously demonstrated to cause a fail of at least 40% in specific airway conduction (SGaw). Inhalation of FK-888 had no significant effect on baseline SGaw. While the recovery from exercise-induced airway narrowing was significantly faster after treatment with FK-888, the area under the curve for SGaw during the 50 min after exercise was significantly reduced (p < 0.05) and the time taken for the SGaw to recover to within 65% of baseline after exercise was also significantly shorter with FK-888 than with placebo (p < 0.05). However, treatment with FK-888 did not significantly attenuate the maximal fall in SGaw. These results suggest that NK1-receptor-mediated mechanisms are involved in the recovery phase of exercise-induced airway narrowing. The possible mechanisms of these phenomena are discussed.
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U2 - 10.1164/ajrccm.153.3.8630576
DO - 10.1164/ajrccm.153.3.8630576
M3 - Article
C2 - 8630576
AN - SCOPUS:9044235778
VL - 153
SP - 936
EP - 941
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 3
ER -