A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients

Masakazu Ichinose, Motohiko Miura, Hideyuki Yamauchi, Natsuko Kageyama, Masafumi Tomaki, Tatsuya Oyake, Yuzuru Ohuchi, Wataru Hida, Hiroshi Miki, Gen Tamura, Kunio Shirato

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101 Citations (Scopus)

Abstract

Recent reports suggest the involvement of vascular phenomena in exercise- induced asthma. Sensory neuropeptides, such as substance P (SP), which causes airway vascular dilatation and plasma leakage, have been demonstrated to play a role in hyperpnea-induced airway narrowing in animal studies. The purpose of this study was to investigate the importance of tachykinins in exercise- induced airway narrowing in patients with asthma using a selective neurokinin 1-receptor (NK1-receptor) antagonist, FK-888. In a double-blind, placebo- controlled, crossover trial, nine subjects with stable asthma were given FK- 888 (2.5 mg) or placebo by inhalation 20 min before each exercise at a level previously demonstrated to cause a fail of at least 40% in specific airway conduction (SGaw). Inhalation of FK-888 had no significant effect on baseline SGaw. While the recovery from exercise-induced airway narrowing was significantly faster after treatment with FK-888, the area under the curve for SGaw during the 50 min after exercise was significantly reduced (p < 0.05) and the time taken for the SGaw to recover to within 65% of baseline after exercise was also significantly shorter with FK-888 than with placebo (p < 0.05). However, treatment with FK-888 did not significantly attenuate the maximal fall in SGaw. These results suggest that NK1-receptor-mediated mechanisms are involved in the recovery phase of exercise-induced airway narrowing. The possible mechanisms of these phenomena are discussed.

Original languageEnglish
Pages (from-to)936-941
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Volume153
Issue number3
DOIs
Publication statusPublished - 1996 Jan 1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Ichinose, M., Miura, M., Yamauchi, H., Kageyama, N., Tomaki, M., Oyake, T., Ohuchi, Y., Hida, W., Miki, H., Tamura, G., & Shirato, K. (1996). A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. American journal of respiratory and critical care medicine, 153(3), 936-941. https://doi.org/10.1164/ajrccm.153.3.8630576