A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases

Etsuro Nanishi, Takayuki Hoshina, Hidetoshi Takada, Masataka Ishimura, Hisanori Nishio, Takahiro Uehara, Yumi Mizuno, Shunji Hasegawa, Shouichi Ohga, Masayoshi Nagao, Maiko Igarashi, Shuhei Yajima, Yoshio Kusumoto, Noriko Onishi, Yoji Sasahara, Takahiro Yasumi, Toshio Heike, Toshiro Hara, Chie Kobayashi, Takashi IshigeKanako Kudo, Kyouko Suzuki, Shohei Ogata, Masako Kikuchi, Yachiyo Kurihara, Ryo Niiya, Tomohiro Katsuta, Yutaka Saikawa, Hisao Yoshida, Yuko Ishizaki, Akira Hayakawa, Toshihiko Shirakawa, Toshihiko Mori, Yutaka Suzuki, Hideo Tsuda, Tomoko Sato, Tomoko Waragai, Satoru Kumaki, Osamu Komiyama, Masumi Seto, Ryo Kadoya, Noriko Ohbuchi, Hiroko Kozan, Hiroyuki Shimizu, Tomoyuki Imagawa, Yoshiyuki Yamada, Takuya Hara, Takuro Ohno, Eiji Ota, Hiroyuki Toda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041; and 14.0 vs 6.0 days, p = 0.031, respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.

Original languageEnglish
Pages (from-to)358-368
Number of pages11
JournalJournal of Infection
Volume73
Issue number4
DOIs
Publication statusPublished - 2016 Oct 1

Keywords

  • Cellular immunodeficiency
  • Influenza virus
  • Primary immunodeficiency diseases
  • Respiratory syncytial virus
  • Rotavirus
  • Varicella-zoster virus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Nanishi, E., Hoshina, T., Takada, H., Ishimura, M., Nishio, H., Uehara, T., Mizuno, Y., Hasegawa, S., Ohga, S., Nagao, M., Igarashi, M., Yajima, S., Kusumoto, Y., Onishi, N., Sasahara, Y., Yasumi, T., Heike, T., Hara, T., Kobayashi, C., ... Toda, H. (2016). A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. Journal of Infection, 73(4), 358-368. https://doi.org/10.1016/j.jinf.2016.07.018