A nanofluidic-based enzymatic reaction on a chip

Takehiko Tsukahara, Eiichiro Tamaki, Akihide Hibara, Takehiko Kitamori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report enzymatic reaction inside extended-nano spaces (101 - 102 nm) on a chip by using pressure-driven nanofludic control system. We examined the kinetic parameters of enzyme in the extended-nano spaces. The results showed that a first-order rate constant (kcat) for a nanospace was increased by a factor of about two compared with bulk and micro spaces. This is first observation of nanofluidic-based enzymatic reactions.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1574-1576
Number of pages3
ISBN (Electronic)9780979806407
Publication statusPublished - 2007
Externally publishedYes
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 2007 Oct 72007 Oct 11

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period07/10/707/10/11

Keywords

  • Enzymatic reaction
  • Extended-nano space
  • Nanofluidics
  • Pressure-driven

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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