A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m 2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors

Fumiaki Isohashi, Tadao Takano, Mamiko Onuki, Takahide Arimoto, Naoki Kawamura, Ryusuke Hara, Yoshiaki Kawano, Yukinobu Ota, Haruo Inokuchi, Hidenori Shinjo, Toshiaki Saito, Satoe Fujiwara, Takashi Sawasaki, Ken Ando, Koji Horie, Hiroyuki Okamoto, Naoya Murakami, Yoko Hasumi, Takahiro Kasamatsu, Takafumi Toita

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the effects of treatment with both three-dimensional radiotherapy (3DRT) and weekly 40-mg/m 2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors. Methods: We conducted a retrospective multi-institutional chart review of postoperative uterine cervical cancer patients with high-risk prognostic factors who had been treated with both 3DRT and weekly 40-mg/m 2 cisplatin from 2007 to 2012. Each participating hospital provided detailed information regarding patient characteristics, treatment outcomes, and treatment complications. Results: The eligible 96 patients were analyzed. The median follow-up period was 61 months. The 3-year relapse-free survival, overall survival (OS), and locoregional relapse-free survival (LRFS) rates were 76%, 90%, and 88%, respectively. In multivariate analysis, the histological finding of either adenocarcinoma or adenosquamous carcinoma was a significant risk factor for both OS and LRFS. The percentage of patients with grade ≥ 3 acute hematologic toxicity, acute lower gastrointestinal toxicity (GIT), and late lower GIT were 45%, 19%, and 17%, respectively. Conclusions: The outcomes of concurrent chemoradiotherapy (CCRT) using weekly 40-mg/m 2 cisplatin are similar to those in the previous studies that used several chemotherapy regimens. However, postoperative CCRT using 3DRT had a high level of late GIT.

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume24
Issue number5
DOIs
Publication statusPublished - 2019 May 15

Keywords

  • Cervical cancer
  • Cisplatin
  • Concurrent chemoradiotherapy
  • Postoperative
  • Three-dimensional radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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