A multi-center prospective study randomizing the use of fat emulsion in intensive glucose control after allogeneic hematopoietic stem cell transplantation using a myeloablative conditioning regimen

Shigeo Fuji, Sung Won Kim, Shigemi Kamiya, Takahiko Nakane, Kenji Matsumoto, Yasushi Onishi, Kimikazu Yakushijin, Etsuko Yamazaki, Masayuki Hino, Saiko Kurosawa, Ken ichi Yoshimura, Takahiro Fukuda

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1 Citation (Scopus)

Abstract

Background & aims: Although parenteral nutrition (PN) is often used after allogeneic hematopoietic stem cell transplantation (allo-HSCT), there is controversy regarding PN management, for instance in the use of fat emulsion and glucose control (GC). To clarify these issues, we conducted a multi-center prospective study with intensive GC, randomizing the use of fat emulsion after allo-HSCT using a myeloablative conditioning regimen. Methods: The primary endpoint was the cumulative incidence of documented infectious disease, namely bacterial and fungal infection, at day 100 after allo-HSCT. Between August 2007 and March 2012, we enrolled 81 patients at 5 centers. Excluding 5 ineligible patients, 76 patients received the protocol treatment. The target fasting glucose level was 80–110 mg/dL. Results: The median follow-up of surviving patients was 1796 days. The cumulative incidences of documented infectious disease at day 100 were 16% (95% confidence interval [CI] 6–29%) in the no-fat group and 19% (95% CI 8–32%) in the fat group, indicating no significant difference. The mean glucose level at 28 days after allo-HSCT was 107 mg/dL in the no-fat group and 111 mg/dL in the fat group. Grade 3 hyperglycemia (>250 mg/dL) and grade 3 hypoglycemia (<40 mg/dL) occurred in 4 patients each (5.3%). Overall survival and non-relapse mortality rates at 4 years were 75% and 11% in the no-fat group and 69% and 8% in the fat group, respectively. Conclusions: Irrespective of the use of fat emulsion, the long-term clinical outcomes of the enrolled patients were favorable under intensive GC. To further clarify the benefits of GC after allo-HSCT, a prospective study randomizing the level of GC is warranted.

Original languageEnglish
Pages (from-to)1534-1540
Number of pages7
JournalClinical Nutrition
Volume37
Issue number5
DOIs
Publication statusPublished - 2018 Oct

Keywords

  • Allogeneic transplantation
  • Fat emulsion
  • Glucose control
  • Hyperglycemia

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Critical Care and Intensive Care Medicine

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