A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal

Kousuke Baba, Hideyuki Dekimoto, Daisuke Muraoka, Kiyokazu Agata, Toshio Terashima, Yu Katsuyama

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Reelin is a glycoprotein secreted by specific neuronal populations of the adult and developing nervous system of vertebrates. The morphological abnormalities in the brain of reeler, the Reelin deficient mutant mice, indicate that Reelin is essential for the brain morphogenesis. However, biochemical function of Reelin signal is not well understood. Here, we examined possible function of Reelin signal in regulation of gene expression by performing a microarray analysis. We found that expression level of a mouse homologue of Strawberry Notch (mSno1) is markedly reduced in the reeler embryos. In situ hybridization showed that mSno1 is expressed in the developing nervous system colocalizing with expression of ApoER2, a Reelin receptor. Treatment of P19 cells with Reelin protein enhanced mSno1 expression. Overexpression of ApoER2 with Reelin treatment gave a synergistic effect on mSno1 expression level. These observations suggest that Reelin signal is involved in embryonic expression of a novel vertebrate gene, mSno1.

    Original languageEnglish
    Pages (from-to)842-849
    Number of pages8
    JournalBiochemical and biophysical research communications
    Volume350
    Issue number4
    DOIs
    Publication statusPublished - 2006 Dec 1

    Keywords

    • Brain development
    • Gene expression
    • Reelin signal
    • Strawberry notch

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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