A model system for studying superselective radiotherapy of lymph node metastasis in mice with swollen lymph nodes

Ryohei Kikuchi, Ariunbuyan Sukhbaatar, Maya Sakamoto, Shiro Mori, Tetsuya Kodama

Research output: Contribution to journalArticle

Abstract

Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalClinical and Translational Radiation Oncology
Volume20
DOIs
Publication statusPublished - 2020 Jan

Keywords

  • Abscopal effect
  • Lymph node
  • Metastasis
  • Mouse model
  • Radiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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