Abstract
With a view to expand the repertoire of chemoselective methods applicable to sensitive and multifunctional substrates, the p-methoxybenzylation of alcohols under essentially neutral conditions is reported. This was achieved by the silver triflate (AgOTf) activation of 5-(p-methoxybenzylthio)-1-phenyl-1H-tetrazole (PMB-ST) in the presence of 2,6-di-tert-butyl-4-methylpyridine (DTBMP).
| Original language | English |
|---|---|
| Pages (from-to) | 5267-5269 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 50 |
| Issue number | 37 |
| DOIs | |
| Publication status | Published - 2009 Sep 16 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Kotturi, S. R., Tan, J. S., & Lear, M. J. (2009). A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid-base activation. Tetrahedron Letters, 50(37), 5267-5269. https://doi.org/10.1016/j.tetlet.2009.07.020