A mild method for the protection of alcohols using a para-methoxybenzylthio tetrazole (PMB-ST) under dual acid-base activation

Santosh R. Kotturi, Jason S. Tan, Martin J. Lear

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

With a view to expand the repertoire of chemoselective methods applicable to sensitive and multifunctional substrates, the p-methoxybenzylation of alcohols under essentially neutral conditions is reported. This was achieved by the silver triflate (AgOTf) activation of 5-(p-methoxybenzylthio)-1-phenyl-1H-tetrazole (PMB-ST) in the presence of 2,6-di-tert-butyl-4-methylpyridine (DTBMP).

Original languageEnglish
Pages (from-to)5267-5269
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number37
DOIs
Publication statusPublished - 2009 Sep 16

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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