Abstract
With a view to expand the repertoire of chemoselective methods applicable to sensitive and multifunctional substrates, the p-methoxybenzylation of alcohols under essentially neutral conditions is reported. This was achieved by the silver triflate (AgOTf) activation of 5-(p-methoxybenzylthio)-1-phenyl-1H-tetrazole (PMB-ST) in the presence of 2,6-di-tert-butyl-4-methylpyridine (DTBMP).
Original language | English |
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Pages (from-to) | 5267-5269 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 50 |
Issue number | 37 |
DOIs | |
Publication status | Published - 2009 Sep 16 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry