A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc

Tetsuji Kubo, Chiharu Katoh, Ken Yamada, Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

A unique combination of CuI and CsOAc was found to catalyze aryl amination under mild conditions. The reaction takes place at room temperature or at 90 °C with broad functional group compatibility. The intramolecular reaction was able to form five-, six-, and seven-membered rings with various protecting groups on the nitrogen atom. The scope of the intermolecular amination, as well as its applications to unsymmetrical N,N′-dialkylated phenylenediamines, was investigated.

Original languageEnglish
Pages (from-to)11230-11236
Number of pages7
JournalTetrahedron
Volume64
Issue number49
DOIs
Publication statusPublished - 2008 Dec 1

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A mild inter- and intramolecular amination of aryl halides with a combination of CuI and CsOAc'. Together they form a unique fingerprint.

  • Cite this