A microfluidic model of the human placenta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of human placenta models is important for understanding the complex systems of the human placenta. To develop the models, we recently established a human trophoblast stem (TS) cell line. We have attempted to fabricate a microfluidic device that recapitulates the function of extravillous cytotrophoblast (EVT) cells that remodel the maternal blood vessels. In our device, the TS cells were successfully differentiated into EVT cells, and EVT cells were able to be co-cultured with vascular networks of human umbilical vein endothelial cells (HUVEC). This device may be a useful tool to analyze the function of EVT cells in detail.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages921-922
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 2020 Oct 42020 Oct 9

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period20/10/420/10/9

Keywords

  • Extravillous cytotrophoblast
  • Human trophoblast stem cells
  • Microfluidics
  • Organ-on-a-chip
  • Vascular networks

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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