TY - GEN
T1 - A microfluidic device for DNA tile self-assembly
AU - Somei, Koutaro
AU - Kaneda, Shohei
AU - Fujii, Teruo
AU - Murata, Satoshi
PY - 2006/7/13
Y1 - 2006/7/13
N2 - This paper presents a microfluidic device specially designed for DNA tile self-assembly. The DNA tile is one of the most promising building blocks for complex nanostructure, which can be used as a molecular computer or a scaffold for functional molecular machineries. In order to build desired nanostructure, it is necessary to realize errorless self-assembly under thermal fluctuation. We propose a method to directly control environmental parameters of DNA self-assembly such as concentration of each monomer tile and temperature in the reaction chamber by using a microfluidic device. The proposed device is driven by a capillary pump and has an open reaction chamber which enables real-time observation by AFM. Results of preliminary experiments to evaluate performance of the device will be reported.
AB - This paper presents a microfluidic device specially designed for DNA tile self-assembly. The DNA tile is one of the most promising building blocks for complex nanostructure, which can be used as a molecular computer or a scaffold for functional molecular machineries. In order to build desired nanostructure, it is necessary to realize errorless self-assembly under thermal fluctuation. We propose a method to directly control environmental parameters of DNA self-assembly such as concentration of each monomer tile and temperature in the reaction chamber by using a microfluidic device. The proposed device is driven by a capillary pump and has an open reaction chamber which enables real-time observation by AFM. Results of preliminary experiments to evaluate performance of the device will be reported.
UR - http://www.scopus.com/inward/record.url?scp=33745748005&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745748005&partnerID=8YFLogxK
U2 - 10.1007/11753681_25
DO - 10.1007/11753681_25
M3 - Conference contribution
AN - SCOPUS:33745748005
SN - 3540341617
SN - 9783540341611
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 325
EP - 335
BT - DNA Computing - 11th International Workshop on DNA Computing, DNA11, Revised Selected Papers
T2 - 11th International Workshop on DNA Computing, DNA11
Y2 - 6 June 2005 through 9 June 2005
ER -