A microfluidic device for DNA tile self-assembly

Koutaro Somei, Shohei Kaneda, Teruo Fujii, Satoshi Murata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

This paper presents a microfluidic device specially designed for DNA tile self-assembly. The DNA tile is one of the most promising building blocks for complex nanostructure, which can be used as a molecular computer or a scaffold for functional molecular machineries. In order to build desired nanostructure, it is necessary to realize errorless self-assembly under thermal fluctuation. We propose a method to directly control environmental parameters of DNA self-assembly such as concentration of each monomer tile and temperature in the reaction chamber by using a microfluidic device. The proposed device is driven by a capillary pump and has an open reaction chamber which enables real-time observation by AFM. Results of preliminary experiments to evaluate performance of the device will be reported.

Original languageEnglish
Title of host publicationDNA Computing - 11th International Workshop on DNA Computing, DNA11, Revised Selected Papers
Pages325-335
Number of pages11
DOIs
Publication statusPublished - 2006 Jul 13
Externally publishedYes
Event11th International Workshop on DNA Computing, DNA11 - London, ON, Canada
Duration: 2005 Jun 62005 Jun 9

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3892 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other11th International Workshop on DNA Computing, DNA11
Country/TerritoryCanada
CityLondon, ON
Period05/6/605/6/9

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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