A marked difference in the vasopressin responsiveness between the adrenal glands in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia

Misaki Miyata, Masanori Yoshida, Junji Shinoda, Hironobu Sasano, Yutaka Oiso

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We herein present the case of a 53-year-old patient with adrenocorticotropin-independent macronodular adrenocortical hyperplasia (AIMAH), which is a rare form of Cushing syndrome. He had hypercortisolemia and bilateral macronodular adrenal glands with a left side predominance. The administration of vasopressin significantly increased the plasma cortisol level (1.9-fold). Following left adrenalectomy, the patient's hypercortisolemia significantly improved and vasopressin responsiveness was lost, suggesting that the responsiveness originated from the resected left adrenal gland. The marked difference in vasopressin responsiveness between the adrenals corresponded with their asymmetrical size and function. Evaluating the differences in the vasopressin sensitivity may therefore be helpful for understanding the progression of AIMAH.

Original languageEnglish
Pages (from-to)1073-1078
Number of pages6
JournalInternal Medicine
Volume52
Issue number10
DOIs
Publication statusPublished - 2013 May 15

Keywords

  • Adrenocorticotropin-independent macroadrenal hyperplasia
  • Cushing syndrome
  • Vasopressin receptor
  • Vasopressin responsiveness

ASJC Scopus subject areas

  • Internal Medicine

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