A marked decrease of orexin in the cerebrospinal fluid in a patient with myotonic dystrophy type 1 showing an excessive daytime sleepiness

Tomoaki Iwata, Naoki Suzuki, Hideki Mizuno, Ichiro Nakashima, Takashi Kanbayashi, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Excessive daytime somnolence is one of the common complaints in patients with myotonic dystrophy. Here we report a 60-year-old female case of myotonic dystrophy type 1 with narcolepsy due to medical condition. The size of the CTG repeat in the 3' untranslated region of the DMPK gene was 1,800-2,400 repeats. Brain MRI was normal. Polysomnography revealed sleep apnea and chronic alveolar hypoventilation. Multiple sleep latency tests revealed normal sleep latencies and sleep onset REM was not observed. Orexin/hypocretin in the cerebrospinal fluid was markedly decreased to an undetectable level. Such sleep-related disorders may worsen the quality of life and possibly cause sudden death in patients with myotonic dystrophy. Narcolepsy associated with myotonic dystrophy should be evaluated appropriately.

Original languageEnglish
Pages (from-to)437-439
Number of pages3
JournalRinshō shinkeigaku = Clinical neurology
Volume49
Issue number7
DOIs
Publication statusPublished - 2009 Jul

ASJC Scopus subject areas

  • Clinical Neurology

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