A mannose-recognizable chemosensor using gold nanoparticles functionalized with pradimicin, a nonpeptidic mannose-binding natural product

Masaru Enomoto, Yasuhiro Igarashi, Masahide Sasaki, Hiroki Shimizu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

By making use of the distance-dependent optical properties of gold nanoparticles as well as the mannose (Man)-specific binding ability of pradimicin (PRM), we have successfully developed a Man-recognizable chemosensor. The dissociation constant of the chemosensor for Man was estimated to be approximately 10 μM, which was ten times lower than that of PRM itself. This result may be attributed to a cluster effect. Therefore, the chemosensor was capable of recognizing Man residues that have not yet been identified as the binding sites for PRM.

Original languageEnglish
Pages (from-to)2603-2609
Number of pages7
JournalTetrahedron
Volume71
Issue number18
DOIs
Publication statusPublished - 2015 May 6
Externally publishedYes

Keywords

  • Chemosensor
  • Cluster effect
  • Gold nanoparticles
  • Molecular recognition
  • Pradimicin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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