A mammalian scaffold complex that selectively mediates MAP kinase activation

Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier, Jun Yasuda, Roger J. Davis

Research output: Contribution to journalArticlepeer-review

587 Citations (Scopus)


The c-Jun NH2 -terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed- lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

Original languageEnglish
Pages (from-to)1671-1674
Number of pages4
Issue number5383
Publication statusPublished - 1998 Sep 11

ASJC Scopus subject areas

  • General


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