A magnetically guided anti-cancer drug delivery system using porous FePt capsules

Teruaki Fuchigami, Ryo Kawamura, Yoshitaka Kitamoto, Masaru Nakagawa, Yoshihisa Namiki

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Magnetic carriers with efficient loading, delivery, and release of drugs are required for magnetically guided drug delivery system (DDS) as the potential cancer therapy. The present article describes the fabrication of porous FePt capsules approximately 340 nm in diameter with large pores of 20 nm in an ultrathin shell of 10 nm and demonstrates their application to a magnetically guided DDS in vitro. An aqueous anti-cancer drug is easily introduced in the hollow space of the capsules without external stimuli and released to cancer cells on cue through the magnetic shell composed of an ordered-alloy FePt network structure, which exhibits superparamagnetic features at approximately body temperature. The drug-loaded magnetic capsules coated with a lipid membrane are efficiently guided to the cancer cells within 15 min using a NdFeB magnet (0.2 T), and more than 70% of the cancer cells are destroyed.

Original languageEnglish
Pages (from-to)1682-1687
Number of pages6
JournalBiomaterials
Volume33
Issue number5
DOIs
Publication statusPublished - 2012 Feb 1

Keywords

  • Drug delivery
  • Magnetic nanoparticles
  • Magnetic targeting therapy
  • Medical applications
  • Porous capsule

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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