@article{00b1a007ae124adbb4f2ec9c4bad965d,
title = "A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging",
abstract = "Research on controlled drug delivery for cancer chemotherapy has focused mainly on ways to deliver existing anti-cancer drug compounds to specified targets, e.g., by conjugating them with magnetic particles or encapsulating them in micelles. Here, we show that an iron-salen, i.e., μ-oxo N,N'- bis(salicylidene)ethylenediamine iron (Fe(Salen)), but not other metal salen derivatives, intrinsically exhibits both magnetic character and anti-cancer activity. X-Ray crystallographic analysis and first principles calculations based on the measured structure support this. It promoted apoptosis of various cancer cell lines, likely, via production of reactive oxygen species. In mouse leg tumor and tail melanoma models, Fe(Salen) delivery with magnet caused a robust decrease in tumor size, and the accumulation of Fe(Salen) was visualized by magnetic resonance imaging. Fe(Salen) is an anti-cancer compound with magnetic property, which is suitable for drug delivery and imaging. We believe such magnetic anti-cancer drugs have the potential to greatly advance cancer chemotherapy for new theranostics and drug-delivery strategies.",
author = "Haruki Eguchi and Masanari Umemura and Reiko Kurotani and Hidenobu Fukumura and Itaru Sato and Kim, {Jeong Hwan} and Yujiro Hoshino and Jin Lee and Naoyuki Amemiya and Motohiko Sato and Kunio Hirata and Singh, {David J.} and Takatsugu Masuda and Masahiro Yamamoto and Tsutomu Urano and Keiichiro Yoshida and Katsumi Tanigaki and Masaki Yamamoto and Mamoru Sato and Seiichi Inoue and Ichio Aoki and Yoshihiro Ishikawa",
note = "Funding Information: We thank K. Otsu, S. Ono, C. Shimada, K. Kezuka, A. Makino, A. Nagasako (Yokohama City University), T. Ohata and K. Akachi (Yokohama National University), and N. Yasuda (JASRI) for their technical assistance. This work has been supported in part by grants from the Ministry of Health, Labor and Welfare (Y.I.), and the New Energy and Industrial Technology Development Organization (NEDO) (Y.I.), a Grant-in-Aid for Scientific Research on Innovative Areas (22136009) (Y.I.), a grant from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (Y.I.), Next generation Cancer Research Promotion Project of Japan Science and Technology Center (P-direct) (Y.I.), IHI Corporation (H.E. and Y.I.), and a Grant for Research and Development Project from Yokohama City University (Y.I.). Work at ORNL was supported by the Department of Energy, Materials Sciences and Engineering Division (D.J.S.). Work at RIKEN was supported by the Targeted Proteins Research Program of the Ministry of Education, Culture, Sports, Science and Technology (I.H.). This work was also supported by a grant for the Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture.",
year = "2015",
month = mar,
day = "17",
doi = "10.1038/srep09194",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}
