A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140

Hirokazu Tamamura; Younong Xu; Toshio Hattori; Xiaoyan Zhang; Rieko Arakaki; Kenji Kanbara; Akane Omagari; Akira Otaka; Toshiro Ibuka; Naoki Yamamoto; Hideki Nakashima; Nobutaka Fujii

doi:10.1006/bbrc.1998.9871

A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140

Hirokazu Tamamura, Younong Xu, Toshio Hattori, Xiaoyan Zhang, Rieko Arakaki, Kenji Kanbara, Akane Omagari, Akira Otaka, Toshiro Ibuka, Naoki Yamamoto, Hideki Nakashima, Nobutaka Fujii

International Research Institute of Disaster Science (IRIDeS)

Research output: Contribution to journal › Article › peer-review

279 Citations (Scopus)

Abstract

T22 ([Tyr(5,l2), Lys⁷]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. Herein, we report our finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure. In the assays we examined, T140 showed the highest inhibitory activity against HIV-1 entry and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 among all the CXCR4 inhibitors that have been reported up to now.

Original language	English
Pages (from-to)	877-882
Number of pages	6
Journal	Biochemical and biophysical research communications
Volume	253
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.1998.9871
Publication status	Published - 1998 Dec 30

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1006/bbrc.1998.9871

Fingerprint Dive into the research topics of 'A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140'. Together they form a unique fingerprint.

Cite this

A low-molecular-weight inhibitor against the chemokine receptor CXCR4 : A strong anti-HIV peptide T140. / Tamamura, Hirokazu; Xu, Younong; Hattori, Toshio; Zhang, Xiaoyan; Arakaki, Rieko; Kanbara, Kenji; Omagari, Akane; Otaka, Akira; Ibuka, Toshiro; Yamamoto, Naoki; Nakashima, Hideki; Fujii, Nobutaka.

In: Biochemical and biophysical research communications, Vol. 253, No. 3, 30.12.1998, p. 877-882.

Research output: Contribution to journal › Article › peer-review

Tamamura, Hirokazu ; Xu, Younong ; Hattori, Toshio ; Zhang, Xiaoyan ; Arakaki, Rieko ; Kanbara, Kenji ; Omagari, Akane ; Otaka, Akira ; Ibuka, Toshiro ; Yamamoto, Naoki ; Nakashima, Hideki ; Fujii, Nobutaka. / A low-molecular-weight inhibitor against the chemokine receptor CXCR4 : A strong anti-HIV peptide T140. In: Biochemical and biophysical research communications. 1998 ; Vol. 253, No. 3. pp. 877-882.

@article{980aeb849ba549febbc4a02b977521a0,

title = "A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140",

abstract = "T22 ([Tyr(5,l2), Lys7]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. Herein, we report our finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure. In the assays we examined, T140 showed the highest inhibitory activity against HIV-1 entry and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 among all the CXCR4 inhibitors that have been reported up to now.",

author = "Hirokazu Tamamura and Younong Xu and Toshio Hattori and Xiaoyan Zhang and Rieko Arakaki and Kenji Kanbara and Akane Omagari and Akira Otaka and Toshiro Ibuka and Naoki Yamamoto and Hideki Nakashima and Nobutaka Fujii",

year = "1998",

month = dec,

day = "30",

doi = "10.1006/bbrc.1998.9871",

language = "English",

volume = "253",

pages = "877--882",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - A low-molecular-weight inhibitor against the chemokine receptor CXCR4

T2 - A strong anti-HIV peptide T140

AU - Tamamura, Hirokazu

AU - Xu, Younong

AU - Hattori, Toshio

AU - Zhang, Xiaoyan

AU - Arakaki, Rieko

AU - Kanbara, Kenji

AU - Omagari, Akane

AU - Otaka, Akira

AU - Ibuka, Toshiro

AU - Yamamoto, Naoki

AU - Nakashima, Hideki

AU - Fujii, Nobutaka

PY - 1998/12/30

Y1 - 1998/12/30

N2 - T22 ([Tyr(5,l2), Lys7]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. Herein, we report our finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure. In the assays we examined, T140 showed the highest inhibitory activity against HIV-1 entry and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 among all the CXCR4 inhibitors that have been reported up to now.

AB - T22 ([Tyr(5,l2), Lys7]-polyphemusin II) is an 18-residue peptide amide, which has strong anti-HIV activity. T22 inhibits the T cell line-tropic (T-tropic) HIV-1 infection through its specific binding to a chemokine receptor CXCR4, which serves as a coreceptor for the entry of T-tropic HIV-1 strains. Herein, we report our finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure. In the assays we examined, T140 showed the highest inhibitory activity against HIV-1 entry and the strongest inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 among all the CXCR4 inhibitors that have been reported up to now.

UR - http://www.scopus.com/inward/record.url?scp=0032583575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032583575&partnerID=8YFLogxK

U2 - 10.1006/bbrc.1998.9871

DO - 10.1006/bbrc.1998.9871

M3 - Article

C2 - 9918823

AN - SCOPUS:0032583575

VL - 253

SP - 877

EP - 882

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -