TY - JOUR
T1 - A longitudinal study of gray matter volume decline with age and modifying factors
AU - Taki, Yasuyuki
AU - Kinomura, Shigeo
AU - Sato, Kazunori
AU - Goto, Ryoi
AU - Kawashima, Ryuta
AU - Fukuda, Hiroshi
N1 - Funding Information:
We thank K. Inoue and K. Okada for insightful comments and K. Inaba, K. Saito, N. Ishibashi, and H. Masuyama for technical help in collecting data. This study was funded by the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke, the National Institute on Drug Abuse and the U.S. National Cancer Institute. Part of this research was supported by a grant from the Telecommunications Advancement Organisation of Japan. This study was also supported in part by the 21st Century Centre of Excellence (COE) Programme (Ministry of Education, Culture, Sports, Science and Technology; MEXT), entitled “Future Medical Engineering-based Bio-nanotechnology” at Tohoku University, and a grant from the JSPS-CIHR Joint Health Research Programme. This work was also supported by the MEXT Grant-in-Aid for Young Scientists (B), 18790864, and for 20659183.
PY - 2011/5
Y1 - 2011/5
N2 - The rate at which the volume of gray matter declines with normal aging, and whether gender or generational differences affect this rate, remain unclear. Using a longitudinal design over 6 years in 381 healthy community-dwelling individuals, we examined the rate of age-related loss in global gray matter volume, and how gender, generational and cerebrovascular risk factors affected this rate. We collected brain magnetic resonance images of the subjects, and calculated gray matter and intracranial volumes at baseline and follow-up using a fully automated technique. Using these volumes we then calculated the gray matter ratio (GMR), which measures gray matter volume as a percentage of the total intracranial volume. There were significant main effects of age, gender, and body mass index, and an age'gender interaction in the annual percentage change in the GMR (APCGMR). The APCGMR of younger women was lower than that in older women and men. Our results may help in understanding the mechanism(s) of normal brain aging, and in distinguishing neurodegenerative diseases from normal aging.
AB - The rate at which the volume of gray matter declines with normal aging, and whether gender or generational differences affect this rate, remain unclear. Using a longitudinal design over 6 years in 381 healthy community-dwelling individuals, we examined the rate of age-related loss in global gray matter volume, and how gender, generational and cerebrovascular risk factors affected this rate. We collected brain magnetic resonance images of the subjects, and calculated gray matter and intracranial volumes at baseline and follow-up using a fully automated technique. Using these volumes we then calculated the gray matter ratio (GMR), which measures gray matter volume as a percentage of the total intracranial volume. There were significant main effects of age, gender, and body mass index, and an age'gender interaction in the annual percentage change in the GMR (APCGMR). The APCGMR of younger women was lower than that in older women and men. Our results may help in understanding the mechanism(s) of normal brain aging, and in distinguishing neurodegenerative diseases from normal aging.
KW - Aging
KW - Body mass index
KW - Gender difference
KW - Gray matter
KW - Longitudinal
KW - Risk factor
KW - Volumetry
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U2 - 10.1016/j.neurobiolaging.2009.05.003
DO - 10.1016/j.neurobiolaging.2009.05.003
M3 - Article
C2 - 19497638
AN - SCOPUS:79954619889
VL - 32
SP - 907
EP - 915
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 5
ER -