A longitudinal model for variations detection in white matter fiber-bundles

Claudio Stamile, Gabriel Kocevar, Francois Cotton, Salem Hannoun, Francoise Durand-Dubief, Carole Frindel, David Rousseau, Dominique Sappey-Marinier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Processing of longitudinal diffusion tensor imaging (DTI) data is a crucial challenge to better understand pathological mechanisms of complex brain diseases such as multiple sclerosis (MS) where white matter (WM) fiber bundles are variably altered by inflammatory events. In this work, we propose a new fully automated method to detect significant longitudinal changes in diffusivity metrics along WM fiber-bundles. This method consists in two steps: i) preprocessing of longitudinal diffusion acquisitions and WM fiber-bundles extraction, ii) application of a genetic algorithm (GA) to detect 'pathological' changes. This method was applied first, on simulated longitudinal variations, and second, on MS patients longitudinal data. High level of precision, recall and F-Measure were obtained for the detection of small longitudinal changes along the WM fiber-bundles.

Original languageEnglish
Title of host publication2015 22nd International Conference on Systems, Signals and Image Processing - Proceedings of IWSSIP 2015
EditorsShahjahan Miah, Alena Uus, Panos Liatsis
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages57-60
Number of pages4
ISBN (Electronic)9781467383530
DOIs
Publication statusPublished - 2015 Oct 30
Externally publishedYes
Event22nd International Conference on Systems, Signals and Image Processing, IWSSIP 2015 - London, United Kingdom
Duration: 2015 Sep 102015 Sep 12

Publication series

Name2015 22nd International Conference on Systems, Signals and Image Processing - Proceedings of IWSSIP 2015

Conference

Conference22nd International Conference on Systems, Signals and Image Processing, IWSSIP 2015
CountryUnited Kingdom
CityLondon
Period15/9/1015/9/12

Keywords

  • Genetic Algorithm
  • Longitudinal Analysis
  • Multiple Sclerosis
  • Tractography
  • White Matter

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Vision and Pattern Recognition
  • Signal Processing

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