TY - GEN
T1 - A longitudinal model for variations detection in white matter fiber-bundles
AU - Stamile, Claudio
AU - Kocevar, Gabriel
AU - Cotton, Francois
AU - Hannoun, Salem
AU - Durand-Dubief, Francoise
AU - Frindel, Carole
AU - Rousseau, David
AU - Sappey-Marinier, Dominique
PY - 2015/10/30
Y1 - 2015/10/30
N2 - Processing of longitudinal diffusion tensor imaging (DTI) data is a crucial challenge to better understand pathological mechanisms of complex brain diseases such as multiple sclerosis (MS) where white matter (WM) fiber bundles are variably altered by inflammatory events. In this work, we propose a new fully automated method to detect significant longitudinal changes in diffusivity metrics along WM fiber-bundles. This method consists in two steps: i) preprocessing of longitudinal diffusion acquisitions and WM fiber-bundles extraction, ii) application of a genetic algorithm (GA) to detect 'pathological' changes. This method was applied first, on simulated longitudinal variations, and second, on MS patients longitudinal data. High level of precision, recall and F-Measure were obtained for the detection of small longitudinal changes along the WM fiber-bundles.
AB - Processing of longitudinal diffusion tensor imaging (DTI) data is a crucial challenge to better understand pathological mechanisms of complex brain diseases such as multiple sclerosis (MS) where white matter (WM) fiber bundles are variably altered by inflammatory events. In this work, we propose a new fully automated method to detect significant longitudinal changes in diffusivity metrics along WM fiber-bundles. This method consists in two steps: i) preprocessing of longitudinal diffusion acquisitions and WM fiber-bundles extraction, ii) application of a genetic algorithm (GA) to detect 'pathological' changes. This method was applied first, on simulated longitudinal variations, and second, on MS patients longitudinal data. High level of precision, recall and F-Measure were obtained for the detection of small longitudinal changes along the WM fiber-bundles.
KW - Genetic Algorithm
KW - Longitudinal Analysis
KW - Multiple Sclerosis
KW - Tractography
KW - White Matter
UR - http://www.scopus.com/inward/record.url?scp=84961763254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961763254&partnerID=8YFLogxK
U2 - 10.1109/IWSSIP.2015.7314176
DO - 10.1109/IWSSIP.2015.7314176
M3 - Conference contribution
AN - SCOPUS:84961763254
T3 - 2015 22nd International Conference on Systems, Signals and Image Processing - Proceedings of IWSSIP 2015
SP - 57
EP - 60
BT - 2015 22nd International Conference on Systems, Signals and Image Processing - Proceedings of IWSSIP 2015
A2 - Miah, Shahjahan
A2 - Uus, Alena
A2 - Liatsis, Panos
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 22nd International Conference on Systems, Signals and Image Processing, IWSSIP 2015
Y2 - 10 September 2015 through 12 September 2015
ER -