A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells

Torsten Wagner, R. Molina, M. Biselli, M. Canzoneri, T. Schnitzler, T. Yoshinobu, M. J. Scheming

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The metabolic activity of cells can be utilised to indicate the general reaction of them towards the cell environment. Hence, the influence of a specific reagent (e.g., drugs, toxins, growth factors, etc.) in the cell-culture medium can be determined by recording the metabolic activity. The light-addressable potentiometric sensor (LAPS), a field-effect-based chemical sensor, provides a promising technology platform to record the metabolic activity of cells with a spatial resolution. In this work, a portable LAPS device will be introduced which is capable of measuring at 16 different locations within the sensor surface simultaneously. The cultivation and recording of the metabolic activity of CHO (Chinese hamster ovary) cells within the LAPS set-up will be demonstrated.

Original languageEnglish
Title of host publicationTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages1107-1110
Number of pages4
DOIs
Publication statusPublished - 2007 Dec 1
Event4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France
Duration: 2007 Jun 102007 Jun 14

Publication series

NameTRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
CountryFrance
CityLyon
Period07/6/1007/6/14

Keywords

  • Cells
  • Field effect
  • Light-addressable potentiometric sensor
  • Metabolism

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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