A hybrid technique of intracavitary and interstitial brachytherapy for locally advanced cervical cancer: Initial outcomes of a single-institute experience

Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato, Jun Itami

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brachytherapy (HBT) seems to be an effective alternative by improving anatomy-oriented dose optimisation. The purpose of this study was to report initial clinical result for LAUCC treated by HBT. Methods: Between January 2012 and November 2015, 42 patients with LAUCC (T1b2-4a) were treated with primary radiation therapy including HBT. Patients with distant metastasis other than para-aortic lymph node spread were excluded from this study. A retrospective analysis was performed for toxicity evaluation and oncological outcome calculation. Results: Median follow-up was 23.2 months (range 13.2-71.4). Two-year overall survival, progression free survival, and local control rate were 81.6, 54.4, and 80.2%, respectively. Seven patients experienced local recurrence (16.6%). Of those, five were confined to the uterus and two at the parametria. Late adverse events ≥ grade 3 were seen in 3 patients. Conclusions: HBT can generate favorable local control in tumors which cannot be adequately covered by ICBT.

Original languageEnglish
Article number221
JournalBMC Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - 2019 Mar 12

Keywords

  • Brachytherapy
  • Hybrid of intracavitary and interstitial brachytherapy
  • Patterns of recurrence
  • Uterine cervical cancer

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

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