A homologue of human placental protein, PP11, and mouse T cell-specific protein, Tcl-30, in exocrine pancreas of a teleost (Paralichthys olivaceus)

Tohru Suzuki, Anand S. Srivastava, Tadahide Kurokawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We cloned a 1401-bp cDNA encoding a novel pancreatic protein (PPSB) with two cysteine-rich somatomedin B-like domains from Japanese flounder (Paralichthys olivaceus). PPSB is predicted to be composed of 385 amino acids, including a signal sequence. The peptide sequence shares high homology with human placental protein 11 (PP11) and mouse T-cell specific protein (Tcl-30), which both contain a single somatomedin B-like domain. PPSB shares 47% and 44% identity with PP11 and Tcl-30, respectively. The unique point of PPSB is that an additional, somatomedin B-like domain is tandemly inserted. Unlike PP11 and Tcl-30, PPSB mRNA is specifically expressed by the exocrine pancreatic acinar cells, together with trypsinogen. Since PP11 has serine protease activity, it is predicted that its teleost homologue, PPSB, may function as a pancreatic digestive enzyme.

Original languageEnglish
Pages (from-to)325-329
Number of pages5
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume133
Issue number3
DOIs
Publication statusPublished - 2002 Nov 1
Externally publishedYes

Keywords

  • Flounder
  • Pancreas
  • Placental protein 11
  • Somatomedin B
  • T-cell specific protein (Tcl-30)
  • Teleost
  • cDNA

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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