A histopathological study of lymphoepithelial island formation in labial salivary glands in patients with primary Sjogren's syndrome

Yukiko Yamamura, Ken Onodera, Ryo Ichinohasama, Kiyoshi Ooya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The proliferative status of lymphoepithelial islands in the labial salivary glands of primary Sjogren's syndrome (pSS) patients was investigated by counting the number of argyrophilic nucleolar organizer regions (AgNORs) in epithelial cells constituting the islands. The islands were classified into four groups and evaluated in terms of total area and three discrete zones of the islands. In each pSS group, the mean AgNOR number per total island epithelial cell nucleus was significantly higher than in control ductal epithelial cells. The zonal AgNOR number fluctuated during the process of island formation but became more uniform as the islands developed. Furthermore, statistically significant trends among the four pSS groups were observed in the ratio of T lymphocytes, B lymphocytes and plasma cells surrounding the islands. The results indicated that the islands are highly proliferative once island formation begins and that zonal island cell proliferation may be associated with the inflammatory cells.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume29
Issue number3
DOIs
Publication statusPublished - 2000 Mar

Keywords

  • AgNORs
  • Labial salivary glands
  • Lymphoepithelial island
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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