A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori

Hiromitsu Tanaka, Jun Ishibashi, Kosuke Fujita, Yoshiro Nakajima, Aki Sagisaka, Kazuya Tomimoto, Noriko Suzuki, Mikio Yoshiyama, Yoichi Kaneko, Takashi Iwasaki, Tomoya Sunagawa, Kayoko Yamaji, Ai Asaoka, Kazuei Mita, Minoru Yamakawa

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232 Citations (Scopus)

Abstract

A genome-wide analysis of innate immunity-related genes and gene families was conducted using the silkworm, Bombyx mori. We identified orthologs for a large number of genes involved in insect immunity that have been reported from Drosophila melanogaster (Diptera), Anopheles gambiae (Diptera), Apis mellifera (Hymenoptera) and Tribolium castaneum (Coleoptera). B. mori has a unique recognition gene and antimicrobial peptide genes that are not present in the Drosophila, Anopheles, Apis and Tribolium genomes, suggesting a lineage-specific gene evolution for lepidopteran insects. The comparative analysis of the insect immune repertoires indicated a dynamic and flexible gene expansion in recognition, modulation and effector mechanisms due to different selection pressures. Differential gene regulation by different bacterial species was found in PGRP and Serpin genes, suggesting that Bombyx has a highly selective gene regulation system depending on bacterial species.

Original languageEnglish
Pages (from-to)1087-1110
Number of pages24
JournalInsect Biochemistry and Molecular Biology
Volume38
Issue number12
DOIs
Publication statusPublished - 2008 Dec
Externally publishedYes

Keywords

  • Comparative genomics
  • Gene evolution
  • Gene expression
  • Gene family
  • Insect immunity
  • Signaling pathways

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science

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  • Cite this

    Tanaka, H., Ishibashi, J., Fujita, K., Nakajima, Y., Sagisaka, A., Tomimoto, K., Suzuki, N., Yoshiyama, M., Kaneko, Y., Iwasaki, T., Sunagawa, T., Yamaji, K., Asaoka, A., Mita, K., & Yamakawa, M. (2008). A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori. Insect Biochemistry and Molecular Biology, 38(12), 1087-1110. https://doi.org/10.1016/j.ibmb.2008.09.001