A gene family homologous to the S-phase specific gene in higher plants is essential for cell proliferation in Saccharomyces cerevisiae

Masaki Ito, Akira Yasui, Atsushi Komamine

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Previously we reported the isolation and characterization of the gene, cyc07, which was specifically expressed in the S phase during the cell cycle in synchronous cell division cultures of the higher plant, Catharanthus roseus. We found that the yeast Saccharomyces cerevisiae contains two closely related genes which show a high degree of similarity (about 64% at the amino acid level) to cyc07 of C. roseus. Site-directed disruption mutations demonstrated that the two yeast genes, homologous to cyc07, constitute an essential gene family for cell proliferation in yeast cells. Furthermore, the rate of cell proliferation varied with the gene copy number.

    Original languageEnglish
    Pages (from-to)29-33
    Number of pages5
    JournalFEBS Letters
    Volume301
    Issue number1
    DOIs
    Publication statusPublished - 1992 Apr 13

    Keywords

    • Catharanthus roseus
    • Cell cycle
    • Gene sequence
    • Saccharomyces cerevisiae
    • cyc07

    ASJC Scopus subject areas

    • Biophysics
    • Structural Biology
    • Biochemistry
    • Molecular Biology
    • Genetics
    • Cell Biology

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