A gain-of-function mutation in a cytokinin receptor triggers spontaneous root nodule organogenesis

Leïla Tirichine, Niels Sandal, Lene H. Madsen, Simona Radutoiu, Anita S. Albrektsen, Shusei Sato, Erika Asamizu, Satoshi Tabata, Jens Stougaard

Research output: Contribution to journalArticlepeer-review

341 Citations (Scopus)

Abstract

Legume root nodules originate from differentiated cortical cells that reenter the cell cycle and form organ primordia. We show that perception of the phytohormone cytokinin is a key element in this switch. Mutation of a Lotus japonicus cytokinin receptor gene leads to spontaneous development of root nodules in the absence of rhizobia or rhizobial signal molecules. The mutant histidine kinase receptor has cytokinin-independent activity and activates an Escherichia coli two-component phosphorelay system in vivo. Mutant analysis shows that cytokinin signaling is required for cell divisions that initiate nodule development and defines an autoregulated process where cytokinin induction of nodule stem cells is controlled by shoots.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalScience
Volume315
Issue number5808
DOIs
Publication statusPublished - 2007 Jan 5
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'A gain-of-function mutation in a cytokinin receptor triggers spontaneous root nodule organogenesis'. Together they form a unique fingerprint.

Cite this