A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.

Original languageEnglish
Pages (from-to)370-383
Number of pages14
JournalChemistry - An Asian Journal
Volume1
Issue number3
DOIs
Publication statusPublished - 2006 Oct 5
Externally publishedYes

Keywords

  • Antitumor agents
  • Automated synthesis
  • Natural products
  • Synthetic methods
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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