Abstract
Powerful dithiane coupling (A) of two fragments and subsequent macrocyclization by ring-closing metathesis (B) produced the entire 27-membered carbocycle of (+)-pinnatoxin A (1), a major toxic principle responsible for outbreaks of shellfish poisonings in China and Japan. (Chemical equation presented).
Original language | English |
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Pages (from-to) | 6505-6510 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 43 |
Issue number | 47 |
DOIs | |
Publication status | Published - 2004 Dec 3 |
Keywords
- Heterocycles
- Macrocycles
- Natural products
- Spiro compounds
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)