A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc

Ippei Takashima, Yohei Inoue, Nobuyuki Matsumoto, Akira Takagi, Kensuke Okuda

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Labile zinc plays various roles in cells at low concentrations which most fluorescent probes are not able to detect. Here we report a cephem-based probe which coordinates to zinc and zinc-bound water cleaves the scaffold and releases the fluorophore. In addition, the zinc is recycled and reacts with multiple probes, amplifying the signal. This signal amplification system is useful for the detection of intracellular zinc at low concentrations and has potential for further development of probes with a similar molecular design. This journal is

Original languageEnglish
Pages (from-to)13327-13330
Number of pages4
JournalChemical Communications
Volume56
Issue number87
DOIs
Publication statusPublished - 2020 Nov 11
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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