A facile method for synthesis of 1,2-oxazoline derivative of N-acetylglucosamine promoted by potassium fluoride

Shin Ichiro Shoda, Ryuko Izumi, Masako Suenaga, Kenji Saito, Masaya Fujita

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A potassium fluoride-promoted intramolecular cyclization reaction of 2-acetamido-2-deoxy-α-D-glucopyranosyl chloride took place smoothly, giving the corresponding 1,2-oxazoline derivative in good yield. Potassium fluoride behaves as a nucleophile for anomerization of the glycosyl chloride as well as an acid captor to scavenge the protonic acid liberated. This is an extremely practical method for preparation of sugar oxazoline derivatives with simple experimental procedures.

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalChemistry Letters
Issue number2
DOIs
Publication statusPublished - 2002 Feb 5

ASJC Scopus subject areas

  • Chemistry(all)

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