A double blind comparative study on the efficacy of S6472, cefaclor and amoxicillin, in the treatment of bacterial pneumonia

Hidetoshi Shibaki, Takehisa Chimoto, Tooru Nakabayashi, Yoshiro Ishii, Matsumi Tosaka, Hajime Watanabe, Sokichi Onodera, Tetsuo Shimizu, Nobuhiro Sasaki, Yuji Ikeda, Jutaro Shimomura, Hiroyuki Tokunaka, Akira Ujiie, Masahide Shinohara, Takashi Takahori, Yoichi Gocho, Fimiei Kondo, Fumio Nagahama, Akira Saitosh, Kiyofumi IshikawaAkira Suzuki, Yomei Hiraga, Kohki Kikuchi, Tomoko Yamamato, Akio Hirayama, Soichiro Uehara, Mikiya Satoh, Masumi Tomisawa, Kyuichiro Sekine, Tohru Natsuisaka, Masahiko Yamagishi, Hiroshi Takagi, Katsuo Suzuki, Mikihiko Tango, Einosuke Odagaki, Yoshiaki Ichishima, Morokuni Abe, Yoshio Kurihara, Choei Itoh, Keisuke Takeuchi, Tatsuya Ishizuka, Osamu Yajima, Tsuyoshi Kikuiri, Tadashii Murakami, Shinichi Oshima, Kazuo Takebe, Katsuhiro Okamoto, Syuichiro Yoshida, Yoshihiro Kumasaka, Tatsuro Irie, Mitsuo Nakamura, Tadeshi Miyasawa, Masashi Yoneda, Naoyoshi Masaki, Toyochi Tamura, Kohzo Kurahashi, Yuichi Hirai, Hitoshi Yashiro, Norihiko Hirota, Masashi Tamura, Takashi Itoh, Shigeki Mori, Fumitoshi Yamauchi, Kiyoshi Omuro, Hiroshi Ishikawa, Takashi Tsuruya, Hiroshi Kuramitsu, Kotaro Itakura, Yasuyuki Suzuki, Kazutoshi Gomi, Katsuyoshi Moriya, Nobuhisa Satoh, Mikio Matsui, Norimi Kometani, Masao Satoh, Yoshikatsu Nemoto, Kiyoshi Kawamorita, Noboru Asabu, Akio Ebina, Seiichi Aonuma, Tsukasa Yoshida, Hiromi Yaoi, Masaaki Itasawa, Syuji Chiba, Saburo Shindoh, Kiichi Kaishio, Hidetaka Satoh, Kazuo Satoh, Kiyoshi Konno, Kohtaro Oizumi, Akira Watanabe, Hiroyuki Nakai, Kohsaku Nagai, Teruo Hasuike, Izumi Hayashi, Tsugushi Ito, Shigemi Kohsaka, Shigeo Takisawa, Kenkichi Shikanai, Yuzuru Matsumoto

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    The S6472 is a 4: 6 mixture of 2 types of granules of cefaclor (CCL) coated with different films; one type of granules is soluble at low pH's and absorbed in the stomach while the other type is soluble at high pH's and absorbed in the intestine. The difference in absorption sites makes it possible to maintain blood concentrations of the drug at clinically efficient levels for a longer period of time compared with ordinary CCL. The efficacy, safety and usefulness of S6472 in the treatment of bacterial pneumonia was compared with those of ordinary CCL and of amoxicillin (AMPC) by the blind method. The patients entered in this trial were those who had bacterial pneumonia or lung abscess and were 16 years or above of age. The S6472 was given orally for 14 days at a daily dose of 1,500 mg (750 mg each after breakfast and supper), CCL was given at a daily dose of 1,500 mg (500 mg each after every meal), and AMPC at 2,000 mg (500 mg each after every meal and at the bedtime). To make the study blind, placeboes were matched with the test drug so that patients in every treatment group took 4 doses per day. Out of a total of 195 patients thus treated, 179 patients (55 in S6472 group, 62 in CCL group and 62 in AMPC group) were adopted for the evaluation by committee members while 185 patients (58 in S6472 group, 63 in CCL group and 64 in AMPC group) by controllers. When clinical results of the 3 treatment groups were compared, no statistically significant differences were observed in efficacy rates (cure rates), incidences of side effects nor abnormal findings of laboratory tests. From these results of this trial, it is concluded that oral administration of 750 mg of S6472 twice a day (1,500 mg per day) is as effective and useful as that of 500 mg of ordinary CCL 3 times a day (1,500 mg per day) or 500 mg of AMPC 4 times a day (2,000 mg per day) in the treatment of bacterial pneumonia or lung abscess.

    Original languageEnglish
    Pages (from-to)853-886
    Number of pages34
    JournalThe Japanese Journal of Antibiotics
    Volume39
    Issue number3
    DOIs
    Publication statusPublished - 1986 Mar

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Pharmacology (medical)
    • Infectious Diseases

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